Arunima Biswas

Arunima Biswas

Arunima Biswas

Arunima Biswas

Department: Department of Zoology
Phone Number: 09836793528
Institutional E-Mail: arunima10@klyuniv.ac.in
Web URL: https://vidwan.inflibnet.ac.in/myprofile
Educational Qualifications:

Indian Institute of Chemical Biology, Kolkata, INDIA
Degree earned: Doctor of Philosophy (Ph.D), Biochemistry, January 2006 – November 2010 Thesis title: Host-parasite interaction: Modulation of signaling pathways in Macrophage and Leishmania and its impact on parasite infectivity.
Supervisor: Dr. Pijush K. Das
University of Calcutta, Kolkata, INDIA
Degree earned: Master of Science, Zoology, September 2005 – August 2005 First Class in Zoology
Masters Project: Hypothyroid induced differential expression of mitochondrial genes in ovary
Maulana Azad College, University of Calcutta, Kolkata, INDIA, 2003, First Class in Zoology
Degree earned: Bachelor of Science, Zoology
Graduated with First Class in Zoology with Chemistry, Botany as subsidiaries

Awards and Honours (National/International)

• Young Scientist Lecture Award, Translational Cancer Research Conference Translational Cancer Society (TCR), Varanasi, INDIA 2020
Awarded with International Congress of Cell Biology Travel Award for Attending 12th ICCB in Prague. July 2016
• Awarded with American Society of Biochemistry and Cell Biology Travel Award for Attending ASBMB meeting in Boston, USA. April 2015.
• Awarded prestigious DST INSPIRE faculty scheme in Bio-Medical Sciences, DST, India, September 2012
• Best poster award in the Society of Biochemists (SBC, India), CIMAP, Lucknow, India, November 2011
• Third prize in oral presentation in ICOPA, India, AIIMS, New Delhi, October 2010
• Qualified CSIR-NET (Council of Scientific and industrial Research, Govt.of India, National Eligibility Test) in Life Sciences, June 2005
• Awarded the National Scholarship Scheme under Govt. of India for being placed in top 20 students in Bachelors Examination, University of Calcutta, 2003
• Awarded the National Scholarship Scheme sponsored by Govt. of West Bengal in recognition of high rank (49 out of 2, 00, 000 candidates) secured Class X Board Examination

Collaborative Programs

Institutional Collaborations:
Prof. Shital K. Chattopadhyay, Department of Chemistry, University of Kalyani
• Prof. Swati De, Department of Chemistry, University of Kalyani
• Prof Sk. Manirul Islam, Department of Chemistry, University of Kalyani
Dr. Utpal Ghosh, Department of Biophysics and Biochemistry, University of Kalyani
Inter-institutional Collaboration:
• Prof. Urmi Chatterji, Cancer Research Laboratory, Department of Zoology, Ballygunge Science College, University of Calcutta, INDIA.
• Prof. Subikash Biswas, College of Medicine and JNM Hospital, Kalyani Nadia, INDIA
• Dr. Arijit Bhattacharya, Associate Professor, Department of Microbiology, Adamas University, Kolkata INDIA

Research Area:

Research Interest:
Targeting and understanding the cyclic nucleotide signaling in cancer stem cells (with special reference to breast cancer stem cells and cervical cancer stem cells)
Understanding cyclic nucleotide signaling in unicellular eukaryotes like Leishmania
Ongoing Research Statement:
Targeting Breast Cancer Stem Cells with Phosphodiesterase Inhibitors.
Department of Biotechnology, Govt. of West Bengal. Funds Sanctioned: INR 37,00,000. (3 Y) Sanctioned on March 2017.
Comprehensive cell cycle regulation in context of cAMP signaling in eukaryotic pathogen like Leishmania
DST-INSPIRE Project (IFA-12 LSBM-22) December 2012- Till Date. Funds Sanctioned: INR 35,00,000 (5Y)

Teaching Experience:

Brief Summary: Teaching at post-graduate level at Department of Zoology, University of Kalyani. Teaching Experience 08 years
Teaching undergraduate courses in Zoology (Honours and General courses) as assistant Professor in DinabandhuMahavidyalaya, West Bengal State University (2015 March- 2015 November.
Taught undergraduate and post-graduate courses in Zoology and special paper Endocrinology as a Part-time lecturer in Maulana Azad College, Kolkata.
Invited by University of Calcutta, Department of Zoology, to deliver five lectures on Cancer Biology at post-graduate level.
Details of Teaching Experience
2015- Present: Assistant Professor, Department of Zoology, University of Kalyani
Animal Physiology & Biochemistry and Metabolic Processes
Animal Physiology
Physiology of muscles: a) Chemical nature of contractile elements b) Role of structural and regulatory proteins in muscular contraction c) ATP and signal molecules in muscular contraction
Synaptic and functional transmission; a) Pre-and postsynaptic structure and function b) Chemical transmission of synaptic activity
Biochemistry and Metabolic Processes
Proteins: Protein folding and protein stability.
Amino-acid metabolism: a) Urea Cycle
Biosynthesis of transport of cholesterol
Enzymes: Kinetic analysis of enzyme-catalyzed reaction b) Regulation of enzyme activity c) Allosteric control of enzyme activity
Brief knowledge of growth factors and their mechanism of action in normal cell growth.
Apoptosis: the concept, mechanism and importance.
Immunology
Complement system: classical pathway and the alternative pathway
Major histocompatibility complex: T -Cell receptors, MHC genes and gene products
Vaccination and immunization: natural and artificial immunization; active immunization, vaccines.
Biomembranes: Transport across cell membrane diffusion; carrier bound transport; active transport and pumps; uniport, symport and antiport
Cell-to-cell signaling: cell surface receptor and nuclear receptor; Second messenger system; MAP kinase pathways
Endocrinology
Phylogeny of Endocrine Glands: pituitary and adrenal.
Biosynthesis, secretion and regulation of hormones: biosynthesis of protein and peptide hormones (Growth Hormone and Insulin), Post-Translational event und release; biosynthesis of steroid hormones and their regulations; biosynthesis of T3 and ‘1 \ and their regulation
Neuroendocrine system and neurosecretion: neural control of glandular secretion; hypothalamic pituitary unit
Physiological role of hormones: hormonal regulation of mineral metabolism and fluid volume; pineal gland hormones and their role in photoperiodic response in vertebrates
Mechanism of hormone action: hormones that acts at the cell surfaceproperties of the hormones- receptor interaction; Cellular mechanism of action
Endocrine techniques
Principles and applications of High Performance Liquid Chromatography (HPLC), Ultra-centrifugation, Ion-exchange chromatography and gel electrophoresis in endocrine research.
Recombinant DNA technology- its application in endocrine research
A). Principles and techniques of Southern, Northern and Western Blotting
B). Polymerase Chain reaction (PCR), definition, technique and application Principles of radio-immuno Assay (RIA) and ELISA Unit-II
Molecular Biology of endocrine signaling
Signaling of peptide hormone and epinephrine a) G-protein coupled receptors and their effectors- mechanism of receptor binding, bacterial toxin that modify the G-protein b) Activation of Adenylate-cyclase system
Receptor Tyrosine kinases (RTKs), Ras and Raf a). Autophosphorylation of RTKs b) Role of adapter protein and guanine nucleotide exchange factor in activation of Ras
MAP kinase pathway, multiple MAP kinase pathways.
Second Messengers and activation of protein kinases A). Protein kinase A B). Protein kinase C C). Calcium-calmodulin signaling D). cGMP 5. Signaling of cytokines and growth hormones.
Ion channel receptor, orphan receptors

Administrative Experiences

External Responsibility/ Admin Responsibility:
Member, AQAR Committee, University of Kalyani
Member, Purchase Committee, MBBT, University of Kalyani
Member, European Association for Cancer research
Member, American Society of Cell Biology (ASCB)
Member, Technical Specification Committee, DBT-BOOST, University of Kalyani
Member, Board of Studies, Belur Vidyamandir, Belur Ramkrishnamission
IBSC External Committee Member, Coochbehar Panchanan Burma University
Paper Setter/ Examiner, University of Calcutta, Gourbanga University, Coochbehar Panchanan Burma University

List of Publications(Peer-Reviewed)

1. Mukherjee P., Bagchi A., Banerjee A., Roy H., Biswas A*., Chatterji U. (2022) PDE4 inhibitor eliminates breast cancer stem cells via non-canonical activation of mTOR Journal of Cellular Biochemistry (IF 2021: 4.23) Ahead of Print (*Co-corresponding)
2. Jeet Banerjee, Anindita Bhattacharjee, Arunima Biswas*, Shital K. Chattopadhyay* Synthesis, Bio-physical and anti-Leishmanial studies of some novel indolo[3,2-a] phenanthridine derivatives(2022) Bioorganic Chemistry (IF 2021: 5.27) (*Co-corresponding) Volume 123, June 105766
3. Bhaduri R., Mandal S., Tarai S. K., Pan A., Mukherjee S., Bagchi A., Biswas A. (2022) Cytotoxic activity of sulfur and oxygen chelated Pt (II) complexes; their DNA/BSA binding by in vitro and in silico approaches. Journal of Molecular Liquids Accepted, Ahead of Print
4. Saha A., Bhattacharjee A., Vij A., Das P. K., Bhattacharya A*, Biswas A. * (2020). Evaluation of Modulators of cAMP-Response in Terms of Their Impact on Cell Cycle and Mitochondrial Activity of Leishmania donovani. Fron. in Pharmacol. 11:782 DOI:10.3389/fphar.2020.00782 ISSN=1663-9812. Impact Factor 5.98 * Co-corresponding author
5. Biswas A., Bhattacharya A., Vij A. and Das PK. (2018) How Unicellular Pathogen Like Leishmania Survive Change in the Environment While Infecting Mammalian Macrophages? Proceedings of UGC-SAP National Seminar on “Effect of Climate Change on Faunal Diversity”. Department of Zoology, University of Kalyani, Kalyani, West Bengal, India. ISBN- 978-81-932401-2-0
6. Biswas A., Bhattacharya A., Vij A., and Das P.K. (2017), Role of leishmanial acidocalcisomal pyrophosphatase in the cAMP homeostasis in phagolysosome conditions required for intra- macrophage survival. Inter. J. Bio Chem. Cell Biol. 86, 1-13 Impact Factor 3.98.
7. Vij A.1, Biswas A.1, Bhattacharya A., Das P.K., A novel cytosolic phosphodiesterase (Ld- PDED) in Leishmania regulates cAMP-dependent protein kinase A signaling in an unique way.(2014) Inter. J. Bio Chem. Cell Biol. 57, 197-206 Impact Factor: 4.2.
8. Saha A., Biswas A., Srivastav S., Mukherjee M., Das P.K. and Ukil A. (2014) Prostaglandin E2 Negatively Regulates the Production of Inflammatory Cytokines/Chemokines and IL-17 in Visceral Leishmaniasis, J. Immunol. 193 (5), 2330-2339 Impact Factor: 5.5.
9. Saha S., Dey S.K., Biswas A., Das P., Das M.R., Jana S.S., (2013) The effect of including the C2 insert of nonmuscle myosin II-C on neuritogenesis, J. Biol. Chem. 288, 7815-7828. Impact Factor: 4.8.
10. Bhattacharya A., Biswas A. and Das P.K., (2012) Identification of a protein kinase A regulatory subunit from Leishmania having importance in metacyclogenesis through induction of autophagy. Mol. Microbiol. 83 (3), 548-564. Impact Factor: 5.01.
11. Biswas A., Bhattacharya A. and Das P.K., (2011) Role of cAMP signaling in the survival and infectivity of the protozoan parasite, Leishmania donovani, Mol. Biol. Int. 2011, 782971. Impact Factor: 1.2.
12. Vassallo O., Castelli S., Biswas A., Sengupta S., Das P.K. , D’Annessa I., Oteri F., Leoni A., Tagliatesta P., Majumder H.K., and Desideri A., (2011) Conjugated Eicosapentaenoic Acid (cEPA) Inhibits L. donovani TopoisomeraseI and has an Antiproliferative Activity AgainstL. donovani Promastigotes, The Open Antimicrob. Agents J. 3, 23-29.
13. Biswas A., Bhattacharya A., Kar S. and Das P.K., (2011) Expression of IL-10-triggered STAT3-dependent IL-4Rα is required for induction of arginase 1 in visceral leishmaniasis, Eur. J. Immunol. 41, 992-1003. Impact Factor: 5.1.
14. Bhattacharya A.2, Biswas A.2 and Das P.K., (2009) Role of a differentially expressed cAMP phosphodiesterase in regulating the induction of resistance against oxidative damage in Leishmania donovani, Free Radical Biol. Med. 47, 1494-1506. Impact Factor: 5.969.
15. Bhattacharya A., Biswas A. and Das P.K., (2008) Role of intracellular cAMP in differentiation- coupled induction of resistance against oxidative damage in Leishmania donovani, Free Radical Biol. Med. 44, 779-794. Impact Factor: 5.969.

Books Published / Book Chapters

1. Bagchi A., Saha P., Biswas A.*, Islam S. M. * (2022) Application of microbes in vaccine production. Book Chapter Springer, Singapore. 573-585. ISBN: 978-981-16-2224-3 * Co-corresponding author
2. Bhattacharjee A, Biswas A*, Das P.K.* (2022) The tale of mastering macrophage environment through the control of inflammasome-mediated macrophage activation and cAMP homeostasis by the protozoan parasite Leishmania. doi: 10.5772/intechopen.102671 (*Co-corresponding)
3. Solanki Sarkar, Amrita Saha, Arunima Biswas*, S.K. Manirul Islam* (2022) Green Sustainable Process for Chemical and Environmental Engineering and Science Biomedical Application of Biosurfactant in Medical Sector Inhibitory activity of biosurfactants against H+-K+ ATPases and defense against gastric ulcers https://doi.org/10.1016/B978-0-323-85146-6.00002-4 * Co-corresponding author
4. Biswas A., Bhattacharjee A and Das P.K (2019). Role of cAMP Homeostasis in Intra-Macrophage Survival and Infectivity of Unicellular Parasites like Leishmania. Current Topics in the Epidemiology of Vector-Borne Diseases (Intech Publications). DOI: 10.5772/intechopen.86360.
5. Chowdhury A.H., Bagchi A., Biswas A*., Islam Sk*. (2018) In Book: Sustainable Polymer composites and nanocomposites. Chapter: Toxicological Evaluation of nanocomposites with special reference to cancer therapy. (Springer Publication) * Co-corresponding author
6. Bagchi A, Saha P., Biswas A. * and Islam Sk*. (2017) Applications of MOFs and their derived materials in molecular transport. Book: Metal-Organic Framework Composites – Volume I, (Materials Research Foundations). DOI: 10.21741/9781644900291. ISBN: 9781644900291 * Co-corresponding author

Invited Lecture / Session Chaired

1. Delivered a invited lecture on Breast Cancer as a Cancer Stem Cell Disease: From Origin to Targeted Therapy (Webinar) in Kingston College of Science, Kolkata on April 09,2021
2. Delivered a lecture on Recent Trends in Diagnosis of Viral Infection: Be it Flu or Cancer. Recent Trends in Biological Sciences. Krishna Nath College, February 05, 2020
3. Animal Biotechnology Techniques: From Cell Culture in vitro to Generation of Transgenic Animals on March 16, 2017. Invited lecture in “Essential Lab Skills and Biotechnology Techniques: From Theory to Bench” Sripat Singh College, Murshidabad, West Bengal. March 14-18, 2017
4. Role of modulators and effector of cAMP signaling pathway in infectivity of Leishmania: exploiting the signaling pathway to for anti-leishmanial targets. Indo-Brazil Symposium, CSIR-Indian Institute of Chemical Biology, Kolkata. September 19-20, 2017.
5. Delivered a DBT-BOOST sponsored invited talk in Maulana Azad College in March 2015

Details of Extra Mural Research Funding

Sl. No Grant Agency Title of The Project Duration / Tenure Total Cost of The Project
1

UGC DAE CSR

Repurposing PDE5 inhibitor encapsulated nanoparticles for the treatment of cervical cancer

3 y

2

DBT, Govt. of W Bengal

TARGETING BREAST CANCER STEM CELLS WITH PHOSPHODIESTERASE INHIBITORSu2019u2019

3 y

38,00,000

3

DST, Govt. of India

Comprehensive cell cycle regulation in context of cAMP signaling in eukaryotic pathogen like Leishmania , Targeting Breast Cancer Stem Cells by Phosphodiesterase Inhibitors

5 years

3500000

Patents

none

Membership of Learned Societies

Member, American Society of Cell Biology (ASCB)

ORCID ID https://orcid.org/0000-0001-5099-6756
SCOPUS ID https://www.scopus.com/authid/detail.uri?authorId=23033387000
Google Scholar ID https://scholar.google.com/citations?user=ArvW_fkAAAAJ&hl=en
VIAF ID Profile URL: https://vidwan.inflibnet.ac.in/profile/195595
Notable Activities

1. Significant Research and Innovation in Science
Dr. Arunima Biswas is presently exploring the field of understanding cAMP modulation in various disease models like breast & cervical cancer in women and in leishmaniasis. Her innovative area of research involves exploiting cAMP-dependent Phosphodiesterase inhibitors (some of which are market available drugs like Sildenafil) as potential anti-cancer and anti-leishmanial targets. She is into repurposing market available or in-trial phosphodiesterase inhibitors in cancer and leishmaniasis. This field of research has brought her several publications and DST-INSPIRE Faculty Award.

Research Supervision

Four Ph.D students.
Mr. Arka Bagchi, DST-INSPIRE SRF, CSIR-NET qualified
Ms. Anindita Bhattacharjee, UGC-SRF
Mr. Solanki Sarkar, URS, LS-NET qualified
Mr. Partha Saha, CSIR-NET quaified
One DBT-RA.
Dr. Amrita Saha
One student received Ph.D

Scholars Awarded

Sl. No Name Photo Current Status
1 Dr. Amrita Saha

DBT-RA

2 Partha Saha

Ongoing

3 Solanki Sarkar

URS-SRF/ Ongoing

4 Anindita Bhattacharjee

UGC-SRF/ ongoing

5 Arka Bagchi

DST-INSPIRE SRF/ ongoing

Research Highlights/Photo gallery