Sk Tofajjen Hossain

Assistant Professor

Department: Department of Microbiology
Phone Number: +917001902413
Institutional E-Mail: tofajjenmicro22@klyuniv.ac.in
Web URL: In progress
Educational Qualifications:

M.Sc., Ph.D.

Research Area:

Small RNA mediated regulation of bacterial physiology, Bacterial RNA metabolism and physiological role of various RNA processing enzymes, Antimicrobial and anti-biofilm activity of phytochemical, Heavy metal bioremediation, Environmental toxicology, Nanotechnology and nanotoxicology.

Teaching Experience:

Assistant Professor (July, 2018 – Present)
Department of Microbiology
Assistant Professor & Head: November, 2016 – July, 2018
Department of Microbiology, Vivekananda Mahavidyalaya, Burdwan
Postdoctoral Associate: April, 2014 – June, 2016
Miller School of Medicine, Department of Biochemistry and Molecular Biology,
University of Miami, Florida, USA.

List of Publications(Peer-Reviewed)

1. Piyali Saha, Samir Kumar Mukherjee, Sk Tofajjen Hossain. Unveiling the role of srbA sRNA in biofilm formation by regulating algU, mucA, rhlA, and rsmA in Pseudomonas aeruginosa. Biochemical Journal. 2025; 482 641–657. https://doi.org/10.1042/bcj20240650
2. Amiya Kar Samir Kumar Mukherjee, Sk Tofajjen Hossain. Quorum sensing mediated attenuation of biofilm formation and virulence traits in Staphylococcus aureus by trigonelline. Microbial Pathogenesis. 2025; 205, 107731. https://doi.org/10.1016/j.micpath.2025.107731
3. Amiya Kar Samir Kumar Mukherjee, Sk Tofajjen Hossain. Regulatory role of PA3299.1 small RNA in Pseudomonas aeruginosa biofilm formation via modulation of algU and mucA expression. Biochemical and Biophysical Research Communications, 2025; 748, 151348. https://doi.org/10.1016/j.bbrc.2025.151348
4. Amiya Kar Samir Kumar Mukherjee, Subhasis Barik, and Sk Tofajjen Hossain. Antimicrobial activity of trigonelline hydrochloride against Pseudomonas aeruginosa and its quorum-sensing regulated molecular mechanisms on biofilm formation and virulence. ACS Infectious Diseases. 2024, 10, 2, 746–762. https://doi.org/10.1021/acsinfecdis.3c00617
5. Pia Dey, Rakesh De, Debaprasad Parai, Sk Tofajjen Hossain, Samir Kumar Mukherjee. Enhanced antimicrobial activity of naringin-ciprofloxacin combination against Pseudomonas aeruginosa PAO1: Unveiling quorum-sensing mediated molecular mechanisms in biofilm formation and virulence. The Microbe. 2024, 5, 100171. https://doi.org/10.1016/j.microb.2024.100171
6. Amiya Kar, Piyali Saha, Rakesh De, Sreyashi Bhattacharya, Samir Kumar Mukherjee, and Sk Tofajjen Hossain. Unveiling the role of PA0730.1 sRNA in Pseudomonas aeruginosa virulence and biofilm formation: Exploring rpoS and mucA regulation. International Journal of Biological Macromolecules. 2024, 279, 135130. https://doi.org/10.1016/j.ijbiomac.2024.135130
7. Piyali Saha, Samir Kumar Mukherjee, and Sk Tofajjen Hossain. Regulation of TCA cycle genes by srbA sRNA: Impacts on Pseudomonas aeruginosa virulence and survival. Biochemical and Biophysical Research Communications, 2024, 737, 150520. https://doi.org/10.1016/j.bbrc.2024.150520
8. Archika Dutta, Samir Kumar Mukherjee, and Sk Tofajjen Hossain. Characterization and exploration of an As(III)-oxidizing bacterium TMKU1 for plant growth promotion under arsenic stress. The Microbe. 2024, 3, 100082. https://doi.org/10.1016/j.microb.2024.100082
9. Archika Dutta, Samir Kumar Mukherjee, and Sk Tofajjen Hossain. Characterization of As(III)-oxidizing bacteria Acinetobacter sp. TMKU7 having plant growth promoting features for possible application in arsenic-contaminated crop field. Bioremediation Journal. 2024, 28(4), 457–471. https://doi.org/10.1080/10889868.2023.2298326
10. Shamayita Basu, Archika Dutta, Samir Kumar Mukherjee, and Sk Tofajjen Hossain. Isolation and characterization of an As(III) oxidizing bacterium, Acinetobacter sp. TMKU4 from paddy field for possible arsenic decontamination. Journal of Hazardous Materials Advances. 2023, 10, 100289. https://doi.org/10.1016/j.hazadv.2023.100289
11. Shamayita Basu, Samir Kumar Mukherjee, and Sk Tofajjen Hossain. Arsenic detoxification by As (III)-oxidizing bacteria: A proposition for sustainable environmental management. Microbiology and Biotechnology Letters. 2023, 51 (1), 1-9. http://dx.doi.org/10.48022/mbl.2212.12003
12. Pia Dey, Debaprasad Parai, Sk Tofajjen Hossain, and Samir Kumar Mukherjee. The aftermath of corona virus disease on antimicrobial resistance across low- and middle-income countries. Universitas Scientiarum. 2023, 28 (2), 183-199. https://doi.org/10.11144/Javeriana.SC282.taoc
13. Pia Dey, Debaprasad Parai, Malabika Banerjee, Sk Tofajjen Hossain, and Samir Kumar Mukherjee. Naringin sensitizes the antibiofilm effect of ciprofloxacin and tetracycline against Pseudomonas aeruginosa biofilm. International Journal of Medical Microbiology. 2020, 310 (3), 151410. https://doi.org/10.1016/j.ijmm.2020.151410
14. Sk Tofajjen Hossain, and Murray P. Deutscher. Helicase activity plays a crucial role for RNaseR function in vivo and for RNA metabolism. The Journal of Biological Chemistry. 2016, 291, 9438–9443. https://doi.org/10.1074/jbc.C116.726091
15. Sk Tofajjen Hossain, Arun Malhotra and Murray P. Deutscher. How RNase R degrades structured RNA: Role of the helicase activity and the S1 domain. The Journal of Biological Chemistry. 2016, 291, 7877–7887. https://doi.org/10.1074/jbc.M116.717991
16. Sk Tofajjen Hossain, Arun Malhotra and Murray P. Deutscher. The helicase activity of ribonuclease R is essential for efficient nuclease activity. The Journal of Biological Chemistry. 2015, 290, 15697–15706. https://doi.org/10.1074/jbc.M115.650176
17. Ivy Mallick, Sk Tofajjen Hossain, Sangram Sinha, and Samir Kumar Mukherjee. Brevibacillus sp. KUMAs2, a bacterial isolate for possible bioremediation of arsenic in rhizosphere. Ecotoxicology and Environmental Safety. 2014, 107, 236-244. https://doi.org/10.1016/j.ecoenv.2014.06.007
18. Sk Tofajjen Hossain and Samir Kumar Mukherjee. Toxicity of cadmium sulfide (CdS) nanoparticles against Escherichia coli and HeLa cells. Journal of Hazardous Materials. 2013, 260, 1073–1082. https://doi.org/10.1016/j.jhazmat.2013.07.005
19. Sk Tofajjen Hossain, Prasenjit Das and Samir Kumar Mukherjee. Toxicity of cadmium nanoparticles to Bacillus subtilis. Toxicological & Environmental Chemistry. 2013, 95(10), 1748–1756. https://doi.org/10.1080/02772248.2014.907902
20. Sudipta Pathak, Kamalesh Debnath, Sk Tofajjen Hossain, Samir Kumar Mukherjee, and Animesh Pramanik. Synthesis of biologically important phthalazinones, 2,3-benzoxazin-1-ones and isoindolinones from ninhydrin and their antimicrobial activity. Tetrahedron Letters. 2013. 54 (24), 3137-3143. https://doi.org/10.1016/j.tetlet.2013.04.015
21. Sk Tofajjen Hossain and Samir Kumar Mukherjee. CdO nanoparticle toxicity on growth, morphology, and cell division in Escherichia coli. Langmuir. 2012, 28(48), 16614–16622. https://doi.org/10.1021/la302872y
22. Sk Tofajjen Hossain, Ivy Mallick, Samir Kumar Mukherjee. Cadmium toxicity in Escherichia coli: Cell morphology, Z-ring formation and intracellular oxidative balance. Ecotoxicology and Environmental Safety. 2012, 86, 54–59. https://doi.org/10.1016/j.ecoenv.2012.09.017

Books Published / Book Chapters

1. Archika Dutta, Samir Kumar Mukherjee, and Sk Tofajjen Hossain. Microbial fuel cell assisted wastewater treatment: A review on current trends. In: Shah, M.P. (eds). Microbial Technologies in Industrial Wastewater Treatment. 2023, Springer, Singapore. https://doi.org/10.1007/978-981-99-2435-6_5
2. Sumita Mondal, Samir Kumar Mukherjee, and Sk Tofajjen Hossain. Exploration of plant growth promoting rhizobacteria (PGPRs) for heavy metal bioremediation and environmental sustainability: Recent advances and future prospects. In: Shah, M.P. (eds). Modern Approaches in Waste Bioremediation. 2023, Springer, Cham. https://doi.org/10.1007/978-3-031-24086-7_3
3. Amit K. Paul, Samir K. Mukherjee, and Sk Tofajjen Hossain. Chapter 23 – Application of nanomaterial in wastewater treatment: recent advances and future perspective. In: Maulin Shah, Susana Rodriguez-Couto, Jayanta Biswas (eds). Development in Wastewater Treatment Research and Processes. 2022, Elsevier, 515-542. https://doi.org/10.1016/B978-0-323-85583-9.00003-X
4. Subhabrata Ghosh, Jayanta Sikdar, Samir K. Mukherjee, and Sk Tofajjen Hossain. Chapter 13 – Use of bioprospecting approach to reveal the potential of various algal species for value added compounds. In: Maulin Shah, Susana Rodriguez-Couto, Celia Bertha Vargas De La Cruz, Jayanta Biswas (eds). An Integration of Phycoremediation Processes in Wastewater Treatment. 2022, Elsevier, 271-288. https://doi.org/10.1016/B978-0-12-823499-0.00013-4
5. Archika Dutta, Shamayita Basu, Samir Kumar Mukherjee, and Sk Tofajjen Hossain. Chapter 21 – Wastewater treatment by microbial biofilm: A distinct possibility. In: Maulin Shah, Susana Rodriguez-Couto (eds). Microbial Ecology of Wastewater Treatment Plants. 2021, Elsevier, 435-468. https://doi.org/10.1016/B978-0-12-822503-5.00013-8
6. Shamayita Basu, Archika Dutta, Samir Kumar Mukherjee, and Sk Tofajjen Hossain. Chapter 9 – Exploration of green technology for arsenic removal from groundwater by oxidation and adsorption using arsenic-oxidizing bacteria and metal nanoparticles. In: Maulin P Shah, Susana Rodriguez Couto, Vineet Kumar (eds). New Trends in Removal of Heavy Metals from Industrial Wastewater. 2021, Elsevier, 177-211. https://doi.org/10.1016/B978-0-12-822965-1.00009-X
7. Ivy Mallick, Sk Tofajjen Hossain, Sangram Sinha, and Samir Kumar Mukherjee. Use of Indigenous Bacteria from Arsenic Contaminated Soil for Arsenic Bioremediation. In: Raju, N., Gossel, W., Sudhakar, M. (eds) Management of Natural Resources in a Changing Environment. 2015, Springer, Cham. https://doi.org/10.1007/978-3-319-12559-6_11