Utpal Ghosh

Professor

Department: Department of Biochemistry and Biophysics
Phone Number: 03325828750
Institutional E-Mail: utpal8ghosh@klyuniv.ac.in
Web URL: klyuniv.ac.in
Educational Qualifications:

1999-2005 Ph.D. from Crystallography & Molecular Biology Division, Saha Institute of Nuclear Physics (SINP), Kolkata, India
1998-1999 Post-M.Sc associateship in Biophysical Sciences, SINP, Kolkata, India
1996-1998 M.Sc in Biophysics, Department of Biochemistry & Biophysics, University of Kalyani, Kalyani-741235, India
1993-1996 Diploma in Pharmacy, State Medical Faculty of West Bengal, Kolkata
1990-1993 B.Sc. (Physics Hons), University of Calcutta, Kolkata, India

Awards and Honours (National/International)

2017 Visiting Research Scientist CEA/DRF-CIMAP/GANIL- LARIA / iRCM, Bd Henri Becquerel – BP 55027, Caen, France
2016 Recipient of European Molecular Biology Organization (EMBO) short-term fellowship- ASTF-282-2016
2015 Recipient of Young Scientist Award from University of Kalyani
2012–2013 Visiting Scientist in ACTREC, Tata Memorial, Mumbai, India, under ‘The Medical Scientists Exchange Programme’ of National Academy of Medical Science (NAMS)
1999-2005 Recipient of JRF/SRF Scholarship from SINP, Kolkata
1998-1999 Recipient of Post-M.Scassociateship Scholarship from SINP, Kolkata
1990–1993 Recipient of Scholarship for the Higher secondary examination, Higher education, Bikash Bhawan, Kolkata, India

Collaborative Programs

MAJOR COLLABORATIONS
1. Dr. Francois Chevalier, Radiobiologist, CEA, CiMAP, GANIL, Caen, France
2. Professor Subhradip Karmakar, Dept. of Biochemistry, AIIMS, New Delhi
3. Dr. Jayitri Mazumdar, Calcutta National Medical College, Kolkata-700014
4. Department of Chemistry, University of Kalyani, Kalyani, India
5. Department of Environment Sciences, University of Kalyani, Kalyani, India
6. Professor Arindam Mukherjee, Dept. of Chemical Sciences, IISER, Kolkata

Research Area:

Our research focuses on the multifaceted role of Poly(ADP-ribose) polymerase-1 (PARP-1) in cancer biology, particularly its involvement in DNA repair, cell death, and cancer progression. About 90% poly(ADP-ribosyl)ation reaction is carried out by PARP-1 isoform, the well-studied member of PARP family protein. PARP-1 is a key enzyme that poly(ADP-ribosyl)ates it’s target proteins, influencing various cellular functions beyond its well-established role in DNA repair. Inhibitors of PARP (PARPi) are currently showing promising results in clinical trials for cancers like BRCA mutant breast and ovarian cancers, as well as pancreatic, colorectal, and prostate cancers. FDA-approved inhibitors such as Olaparib, Rucaparib, and Niraparib are already available for treatment. However, the precise mechanisms of these inhibitors in different cancer types remain poorly understood.
Our research aims to explore the functional characterization of PARP-1 in DNA repair, apoptosis, and metastasis pathways, particularly in response to high and low LET radiation. This involves investigating cluster DNA damage repair and the regulation of cell death and cancer metastasis. We are also screening synthetic compounds and natural products for their anticancer activities.
Another area of interest is the regulation of telomerase activity and telomere length maintenance in mammalian cells, which is a critical factor in cancer progression. Around 85% of cancer cells are telomerase-positive, while most normal cells are not, making telomerase a valuable target for cancer therapy. In addition, PARP-1’s involvement in both the telomerase and ALT (alternative lengthening of telomeres) pathways for telomere maintenance remains unclear, and we aim to elucidate its precise role.
Our key research objectives include:
• Functional characterization of PARP-1 in DNA repair, apoptosis, and metastasis pathways in human cancer cells treated with high LET carbon ion and low LET gamma radiation, as well as synthetic and natural compounds.
• Regulation of telomerase activity and telomere length maintenance in mammalian cells and its implications for human diseases.

Research experience using high LET carbon ion:
Since 2008, our research has focused on the DNA Damage Response (DDR) pathways in various human cancer cell lines following exposure to high LET carbon ion radiation [62 MeV (5.2 MeV/u) with a LET value of 290 KeV/µM]. We utilize the 15UD Pelletron ion beam facility at the Inter-University Accelerator Center (IUAC), New Delhi, for this work.
In our studies, human cancer cells are exposed to varying doses of carbon ion (12C) radiation, both in the presence and absence of PARP-1 inhibitors, to assess DNA damage, repair processes, apoptosis, and metastasis. We have extensively studied the pathways leading to apoptosis induction and metastasis reduction in cancer cells treated with carbon ion radiation. Additionally, we have compared the radiobiological parameters of different human cancer cells exposed to high LET 12C radiation with those treated with low LET gamma radiation.
In 2017, I worked as a visiting scientist with the Radiation Biology team at LARIA, CiMAP, GANIL, Caen, France, as part of a collaborative research project (PROJECT FONDATION ARC 2015, France; Ref no: PJA 20151203177). In this project, we investigated the mechanisms of radio-sensitization by exposing human chondrosarcoma cells to high LET carbon ion and low LET X-rays, with and without PARP-1 inhibitors.
I also conducted research at the Istituto Nazionale di Fisica Nucleare (INFN), Catania, Italy, where we compared the cellular responses of chondrosarcoma cells to both high and low LET radiations. This work has provided important insights into the differential effects of LET on cancer cell response, aiding in the development of more targeted cancer therapies.

Teaching Experience:

18 years experiences
TEACHING ACTIVITIES
Molecular biology – Transcription, post-transcriptional modification, Mutation & polymorphism and its disease relation,
Recombinant DNA technology- Cloning & expression of Proteins, RT-PCR, RAPD, AFLP; RNA interference, etc
Non-coding RNAs: siRNA, miRNA and its relation to diseases
Physic-chemical techniques –Viscosity, Sedimentation,
Biomolecular spectroscopy – Absorption, fluorescence & CD spectroscopy of biomolecules
Medical Biophysics – Radioactivity in biology, Nuclear Medicine, Endoscopy, Fibre optics, principles of Biometry

List of Publications(Peer-Reviewed)

List of publications in Peer-reviewed journals
1. Combined Effects of Carbon Ion Radiation and PARP Inhibitor on Non-Small Cell Lung Carcinoma Cells: Insights into DNA Repair Pathways and Cell Death Mechanisms. Payel Dey, Rima Das, Sandipan Chatterjee, Roni Paul, Utpal Ghosh. DNA Repair (2024) [IF=3.0; Elsevier; Print ISSN: 1568-7864; Online ISSN: 1568-7856;
2. Elevated Telomeric Repeat-Containing RNA (TERRA) Levels Linked to Telomere Dysfunction and Telomerase Inactivity in Blood Cells of Children With Aplastic Anemia. Jayitri Mazumdar, Priyanka Chowdhury, Badal Chandra Mondal, Anjan Kumar Das, Utpal Ghosh. Cureus (2024) [IF=1.2; Springer Nature; ISSN: 2168-8184; DOI: 10.7759/cureus.71241]
3. p38 MAPK inhibitor SB203580 enhances anticancer activity of PARP inhibitor olaparib in a synergistic way on non-small cell lung carcinoma A549 cells. Payel Dey, Soumyajit Biswas, Rima Das, Sandipan Chatterjee, Utpal Ghosh. BBRC (2023) [IF=3.575. Elsevier; 0006-291X (print); 1090-2104 (web)]doi10.1016/j.bbrc.2023.05.116
4. High throughput screening of a new fluorescent G-quadruplex ligand having telomerase inhibitory activity in human A549 cells. Sourav Ghosh, Debapriya De, Victor Banerjee, Soumyajit Biswas, Utpal Ghosh. Nucleosides, Nucleotides & Nucleic Acids (2023) [IF=1.539, Taylor & Francis; Print ISSN 1525-7770; online ISSN:1532-2335]doi.org/10.1080/15257770.2023.2188220
5. Leaf extract and active fractions of Dillenia pentagynaRoxb. reduce in-vitro human cancer cell migration via NF‐κB pathway. Debapriya De, Priyanka Chowdhury, Sujogya Kumar Panda and Utpal Ghosh. Integr Cancer Ther. (2022) [IF=3.538; SAGE Publications; ISSN: 1534-7354 (print) 1552-695X (web)] Nov 23 2022, 21; 1-18, https://doi.org/10.1177/15347354221128832
6. Induction of apoptosis by ethanolic extract of leaf of Dillenia pentagynaRoxb. in A549 cells via NF-κB pathway. Debapriya De, Sujogya Kumar Panda and Utpal Ghosh. Phytomed plus (2022) [IF=NA; Elsevier; ISSN: 0024-3205] 14 Nov 2022; https://doi.org/10.1016/j.phyplu.2022.100368
7. PARP1 modulates telomere sister chromatid exchange and telomere length homeostasis by regulating telomere localization of SLX4 in U2OS cells. Ratan Sadhukhan, Utpal Ghosh. Life Sci (2021) [IF=5.037; Elsevier; ISSN: 0024-3205] Jul 15 [cited 2021 May 18];277:119556. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0024320521005427
8. Gamma ray induced in-vitro cell migration via EGFR/ERK/Akt/p38 activation is prevented by olaparib pre-treatment. Priyanka Chowdhury, Payel Dey, Debaprioya De, Utpal Ghosh. Int J Radiat Biol. (2020) [IF=3.352; Taylor & Francis; ISSN: 0955-3002] Jan 8:1-26. doi: 10.1080/09553002.2020.1711461.
9. Effect of Substitution at Amine Functionality of 2,6-Diaminopyridine-Coupled Rhodamine on Metal-Ion Interaction and Self-Assembly. Santanu Panja, Subhendu Mondal, Sourav Ghosh, Utpal Ghosh, and Kumaresh Ghosh. ACS Omega.[IF=4.132; ACS Publications; ISSN: 2470-1343] 2020 Jun 3; 5, 13984−13993 ;acsomega.0c01384. Available from: https://pubs.acs.org/doi/10.1021/acsomega.0c01384
10. Reduction of metastatic potential by inhibiting EGFR/Akt/p38/ERKsignaling pathway and epithelial-mesenchymal transition after carbon ion exposure is potentiated by PARP-1 inhibition in non-small-cell lung cancer. Priyanka Chowdhury, Payel Dey, Sourav Ghosh, Asitikantha Sarma,Utpal Ghosh*. BMC Cancer (2019) 19:829 . [IF=4.672 BioMed Central;ISSN:1471-2407]
11. Sensitization of chondrosarcoma cells with PARP inhibitor and high-LET radiation.Mathieu Césaire, Utpal Ghosh, Jean-Baptiste Austry, Etienne Muller, Francesco Paolo Cammarata, Marilyne Guillamin, Massimo Caruso, Laurent Castéra, Giada Petringa, Giuseppe Antonio Pablo Cirrone, François Chevalier. J Bone Oncol (2019)vol-17.[IF=4.491, Elsevier; ISSN: 2212-1374]
12. Expression of telomere-associated proteins is interdependent to stabilize native telomere structure and telomere dysfunction by G-quadruplex ligand causes TERRA up-regulation. Ratan Sadhukhan, Priyanka Choudhury, Sourav Ghosh, Utpal Ghosh*. Cell Biochem Biophys.(2018) 2018 Jun;76(1-2):311-319. doi: 10.1007/s12013-017-0835-0.accepted.[IF=2.989, Springer; ISSN: 1085-9195 (Print) 1559-0283 (Online)]
13. Application of cell-free fetal DNA for early evaluation of preeclampsia to reduce maternal mortality by low-cost method – A prospective cohort study. Mriganka Mouli Saha, Deepshikha Mukherjee, Utpal Ghosh and Subir Kumar Das. Indian J Biochem Biophys. [IF=1.476; ISSN: 0975-0959 (Online);0301-1208 (print) ] 2018;55(5):334–40.
14. C-Beam Induces More Chromosomal Damage In Chemo-Radio-Resistant Cells Than O-Beam. Utpal Ghosh, Regina Lichti Binz, Ratan Sadhukhan, Asitikantha Sarma, Subrata Kumar Dey,Martin Hauer-Jensen, Rupak Pathak. Research and Reviews: Journal of Pharmacy and pharmaceutical Sciences. e-ISSN:2320-1215; p-ISSN:2322-0112; 2018;7(2):9–14.
15. RAFT derived fatty acid based stimuli responsive fluorescent block copolymers as DNA sensor and cargo delivery agent. Lakshmipriya Datta, Debapriya De, Utpal Ghosh, Tapan Kumar Das. Polymer[IF=4.231, Elsevier; ISSN:032-3861]. 2018;138:103–12. Available from: https://doi.org/10.1016/j.polymer.2018.01.044
16. Patients with congenital limb anomaly show short telomere, shutdown of telomerase and deregulated expression of various telomere-associated proteins in PBMC; Jayitri Mazumdar1, Priyanka Chowdhury2, Tunisha Bhattacharya1, Badal Chandra Mondal1,Utpal Ghosh1*. J Clin Diagn Res (2017) DOI: 10.7860/JCDR/2017/26960.10516 Aug, Vol-11(8): GR01-GR05 [JCDR Research and Publications (P) Limited.: ISSN – 0973-709X (Online), 2249-782X (Print)]
17. Transcriptional up-regulation of TERT and TERC necessarily not mean higher telomerase activity: A report of telomerase inhibition with higher transcription of TERT, TERC and TERF2 in A549 cells treated with staurosporine. Ratan Sadhukhan and Utpal Ghosh; Int J Biotechnol Bioeng. 2017;3(1):10–5.
18. Insight into the binding of a non-toxic, self-assembling aromatic tripeptide with ct-DNA: Spectroscopic and viscositic studies. Soumi Biswas, Styabrata Samui, Arpita Chakraborty, Sagar Biswas, Debapriya De, Utpal Ghosh, Apurba K Das, Jishu Naskar. Biochem. Biophy. Rep 2017 Jul 8;11:112-118. doi: 10.1016/j.bbrep.2017.07.001. eCollection 2017 Sep.
19. αAmino Acid Derived Benzimidazole-Linked Rhodamines: A Case of Substitution Effect at the Amino Acid Site toward Spiro Ring Opening for Selective Sensing of Al3+ Ions. Anupam Majumdar, Subhendu Mondal, Constantin G Daniliuc, Debashis Sahu, Biswajit Ganguly, Sourav Ghosh, Utpal Ghosh, Kumaresh Ghosh. Inorg. Chem. 2017 Aug 7;56(15):8889-8899. doi: 10.1021/acs.inorgchem.7b00835. Epub 2017 Jul 24. [IF=4.857; ACS Publications; Print ISSN: 0020-1669; Web ISSN: 1520-510X].
20. New cyclic tetranuclear copper(II) complexes containing quadrilateral cores: synthesis, structure, spectroscopy and their interactions with DNA in aqueous solution. Gopal C. Giri,a Shobhraj Haldar,a Aloke Kumar Ghosh,b Priyanka Chowdhury,c Luca Carrella,dUtpal Ghosh,c and Manindranath Bera*. J Molecular Structure (2017) Aug 15, 1142: 175-184. doi.org/10.1016/j.molstruc.2017.04.033[IF=3.841; Elsevier; ISSN: 0022-2860].
21. Two cases of Oto palate digital syndrome type II: Clinical features and a study of telomere length maintenance pathways. Jayitri Mazumdar1, Priyanka Chowdhury2, Arundhati Banerjee1, Tunisha Bhattacharya1, Badal chandra Mondal1, Utpal Ghosh2*. Int J Med Sci Clin Inven. (2016) Dec; DOI: https://dx.doi.org/10.18535/ijmsci/v3i12.11 [VIJ; ISSN: 2348-991X; 2454-9576]
22. PARP-1 depletion in combination with carbon ion exposure significantly reduces MMPs activity and overall increases TIMPs expression in cultured HeLa cells.Atanu Ghorai, Asitikantha Sarma, Priyanka Chowdhury and Utpal Ghosh*; Radiat Oncol (2016) Sep 22; 11(1): 126.DOI: 10.1186/s13014-016-0703-x [IF=4.309 BioMed Central; ISSN: 1748-717X]
23. Synthesis and characterization of two different Cu(II) complexes with a new pyrazole based Schiff base ligand: Crystallography, DNA interaction and antimicrobial activity of Ni(II) and Cu(II) complexes. (Accepted) Susmita Mandal, RatanSadhukhan, Utpal Ghosh, Soumik Mandal, Ray J Butcher, Nitis Chandra Saha.(Accepted) J Coord Chem (2016) March 01, 1618-1634; doi.org/10.1080/00958972.2016.1174773. [IF= 2.012, Taylor & Francis; ISSN: 0095-8972 (Print), 1029-0389 (Online).
24. Carbon ion beam triggers both caspase-dependent and caspase-independent pathway of apoptosis in HeLa and status of PARP-1 controls intensity of apoptosis. Atanu Ghorai, AsitikanthaSarma, Nitai P. Bhattacharyya and Utpal Ghosh*;.Apoptosis (2015)Apr;20(4):562-80. doi: 10.1007/s10495-015-1107-3. [IF=5.561, Springer; ISSN: 1360-8185 (print version), ISSN: 1573-675X (electronic version)]
25. Interaction Studies between Biosynthesized Silver Nanoparticle with Calf Thymus DNA and Cytotoxicity of Silver Nanoparticles; Swarup Roy*, RatanSadhukhan, Utpal Ghosh, and Tapan Kumar Das .Spectrochim Acta A Mol Biomol Spectrosc (2015) Jan 29;141C:176-184. doi: 10.1016/j.saa.2015.01.041 [IF= 4.098; Elsevier; ISSN: 1386-1425].
26. Radiosensitivity and induction of apoptosis by high LET carbon ion beam and low LET gamma radiation: A comparative study. Atanu Ghorai, Nitai P. Bhattacharyya, Asitikantha Sarma and Utpal Ghosh*, Scientifica (2014) vol. 2014, Article ID 438030, 10 pages, 2014. doi:10.1155/2014/438030.[Hindawi Publishing Corporation; ISSN: 2090-908X]
27. miRNA gene counts in chromosome vary widely in a species and biogenesis of miRNA largely depends on transcription or post-transcriptional processing of coding genes. AtanuGhorai, Utpal Ghosh*. Front Genet. (2014) Apr 29;5:100. doi: 10.3389/fgene.2014.00100. eCollection 2014 [Frontiers Community; IF-4.772, ISSN: 1664-8021]
28. Green Synthesis of Gold nanoparticles for staining Human Cervical Cancer Cells and DNA binding assay. Swati De, RiktaKundu, AtanuGhorai, Ranju Prasad Mandal, UtpalGhosh J Photochem Photobiol B (2014) Aug 1;140C:130-139. doi: 10.1016/j.jphotobiol.2014.07.014. [IF=6.814; Elsevier; ISSN: 1011-1344].
29. Synthesis of novel pyrano[3,2-f]quinoline, phenanthroline derivatives and studies of their interactions with proteins: an application in mammalian cell imaging. K.C. Majumdar, Sudipta Ponra, Tapas Ghosh, Ratan Sadhukhan, Utpal Ghosh, Eur J Med Chem (2014) Jan;71:306-15. doi: 10.1016/j.ejmech.2013.10.067. Epub 2013 Nov 2.[IF = 6.514, Elsevier; ISSN: 0223-5234].
30. Induction of apoptosis by benzamide in K562 cells was triggered by inhibition of poly(ADP-ribosyl)ation of protein(s). UtpalGhosh1,*Nitai P. Bhattacharyya. J. Biotechnol. & Biomaterial (2013) January 27, [OMICS Publishing Group; ISSN: 2155-952X].
31. Synthesis, Structure, Spectroscopic Characterization and Protein Binding Affinity of New Water Soluble Hetero- and Homometallic  Tetranuclear [CuII2ZnII2] and [CuII4]  Clusters Ayan Patra, aTamal K. Sen,b Atanu Ghorai, cGhezai T Musie,*dSwadhin K. Mandal, Utpal Ghoshc and Manindranath Bera*a Inorg Chem (2013) 52 (6), pp 2880–2890. [I.F=5.436, American Chemical Society publication; ISSN: 0020-1669].
32. Synthesis, structure, interaction with DNA and cytotoxicity of a luminescent 3 copper(II) complex with a hydrazone ligand Soma Mukherjee, Santanu Chowdhury, AtanuGhorai, Utpal Ghosh, Helen Stoeckli-Evans, Polyhedron. (2013) Volume 51, 4 March 2013, Pages 228-234. [IF=3.052, Elsevier; ISSN: 0277-5387].
33. Biocapped Nanoparticles are More Bioactive to HeLa Cells than its Chemical Counterpart Utpal. Ghosh, Manickkam Nagalakshmi, Ratan. Sadhukhan, Agnishwar Girigoswami, Adv. Sci. Eng. Med. (2013). 5, Number 8, August 2013, pp. 783-788(6). [IF=0.987,American Scientific Publisher; ISSN: 2164-6627].
34. Design and synthesis of anthracene-based bispyridinium amides: anion binding, cell staining and DNA interaction studies. Kumaresh Ghosh, AvikRanjan Sarkar, AtanuGhorai and Utpal GhoshNew J Chem (2012) 36: 1231-45; DOI:10.1039/c2nj21024j. [I.F=3.591, Royal Society of Chemistry publishing; ISSN: 1144-0546].
35. Synthesis, structural characterisation and cytotoxicity of new iron(III) 3 complexes with pyrazolylthiosemicabazones; Nitis Chandra Saha, Chinmoy Biswas, AtanuGhorai, Utpal Ghosh, Saikat Kumar Seth, Tanusree Kar Polyhedron (2012) 34;1-12. [IF=2.975, Elsevier; ISSN: 0277-5387].
36. A new blue luminescent dichlorido-bridged dinuclearcopper(II) complex with DNA binding and cytotoxic activities: Synthesis, structure and DFT studies. Soma Mukherjee, ChamdramaBasu, Santanu Chowdhury, Asoke P. Chattopadhyay, AtanuGhorai, Utpal Ghosh, Helen Stoeckli-Evans. Inorganica Chimica Acta, (2010), 363(12) 2752-61. [I.F=3.118, Elsevier; ISSN: 0020-1693]
37. Interaction of Aurintricarboxylic acid (ATA) with four nucleic acid binding proteins DNase I, RNase A, Reverse transcriptase and Taq polymerase. Utpal Ghosh1,*, Kalyan Giri2 and Nitai P. Bhattacharyya3.Spectrochim Acta A MolBiomolSpectrosc (2009) Dec;74(5):1145-51. Epub 2009 Sep 19. [IF=4.831, Elsevier; ISSN: 1386-1425]
38. Induction of apoptosis by the inhibitors of poly (ADP-ribose) polymerase in HeLa cells. Utpal Ghosh1,* and Nitai P. Bhattacharyya2. Mol Cell Biochem. (2009) 320:15-23. DOI 10.1007/s11010-008-9894-2 [I.F=3.842, Springer; ISSN: 0300-8177 (Print) 1573-4919 (Online)]
39. Resistance to induction of micronuclei, chromosomal aberrations and apoptosis by 60Co γ- ray in a cell strain M5, derived from Chinese hamster V79 cells. Rupak Pathak, A. R. KhudaBukhsh, S. K. Dey, Utpal Ghosh, B. Sen Gupta, M. Semwal, N. P. Bhattacharyya. J Radioanalytical & Nuclear Chemistry (2007) 274: 441-447. DOI: 10.1007/s10967-007-1134-9 [I.F=1.520, Springer; ISSN: 0236-5731 (print version) ISSN: 1588-2780 (electronic version)]
40. Inhibition of telomerase activity by reduction of poly (ADP-ribosyl)ation of TERT and TEP1/TP1 expression in HeLa cells with knocked down poly (ADP-ribose) polymerase-1 (PARP-1) gene. Utpal Ghosh, Nilanjana Das and Nitai P. Bhattacharyya. Mutat Res (2007); 615(1-2); 66-74. [I.F=3.680, Elsevier; ISSN: 0027-5107]
41. Curcumin-induced apoptosis in human leukemia cell HL-60 is associated with inhibition of telomerase activity. Sutapa Mukherjee Nee Chakraborty, Utpal Ghosh, Nitai P. Bhattacharyya, R.K. Bhattacharya, S Dey, Madhumita Roy. Mol Cell Biochem. (2007); 297 (1-2); 31-9.[I.F=2.393, Springer; ISSN: 0300-8177 (Print) 1573-4919 (Online)]
42. Activation of mitochondrial promoter PH –binding protein in a radio-resistant Chinese hamster cell strain associated with Bcl-2. Paromita Roychoudhury, Utpal Ghosh, Nitai P. Bhattacharyya, Keya Choudhury. Biochem. Biophys. Res. Commun., (2006); 350(2); 272-6.[I.F=2.523, Elsevier; ISSN: 0006-291X]
43. Inhibition of telomerase activity and induction of apoptosis by curcumin in K562 cells. Sutapa Chakraborty, Utpal Ghosh, N P Bhattacharyya, R. K. Bhattacharya &Madhumita Roy. Mutat Res. (2006); 596 (1-2); 81-90. [I.F=3.680, Elsevier; ISSN: 0027-5107]
44. Benzamide and 4-amino 1, 8 naphthalimide (NAP) treatment inhibit telomerase activity by down-regulating the expression of telomerase associated protein TEP1/TP1 and inhibiting poly(ADP-ribosyl)ation of TERT in cultured cells. Utpal Ghosh and Nitai P. Bhattacharyya, FEBS J. (2005); 272(16); 4237-48. [I.F=4.001, Wiley; ISSN: 1742-4658]
45. Induction of apoptosis by benzamide and its inhibition by aurintricarboxylic acid (ATA) in Chinese Hamster V79 cells. Utpal Ghosh, Bhaswati Pandit, Jui Dutta, N. P. Bhattacharyya. Mutat Res. (2004); 554; 121-129. [I.F=3.680, Elsevier; ISSN: 0027-5107]
46. Caspase 8 mediated apoptotic cell death induced by β-sheet forming poly alanine peptides Kalyan Giri, Utpal Ghosh., Nitai P. Bhattacharyya, SoumenBasak FEBS Lett.(2003); 555; 380-384. [I.F=3.538, Elsevier; ISSN: 0014-5793]
47. Association of fluorescent probes, ANS and bis-ANS, with T7 RNA polymerase- can they be used for folding studies of the enzyme ?Utpal Ghosh, Mili. Das, DipakDasgupta, Biopolymers (Biospectroscopy). (2003); 72; 249-255.[I.F=2.87, Wiley; ISSN: 0006-3525 (Print) 1097-0282 (Electronic)].

Books Published / Book Chapters

Book Title: Recent Advances in Natural Products
Chapter Title: Telomerase Inhibition and Apoptosis Induction by Natural Products From Plant Origin: Approaches for Cancer Chemotherapy; Utpal Ghosh, Debapriya De, Victor Banerjee. (2015); Studium Press LLC, USA

Invited Lecture / Session Chaired

SELECTED INVITED TALK
1. International Conference on Radiation Research: Impact on Human Health and Environment (ICRR-HHE 2024) and 4th Biennial meeting of Society for Radiation of the Society for Radiation Research-India (SRR) November 22-24, 2024 Venue: AIIMS Patna-801507, Bihar; High LET carbon ion (12C) combined with PARP inhibitor olaparib could be a promising approach of cancer therapy against highly aggresive human non-small lung cancer cells
2. International Conference on Radiation Biology, 19-21, 2022, Department of Zoology, Govt. Dungar College, Bikaner. High LET carbon ion radiotherapy could be a promising approach to approach to cancer therapy against human cancer cells
3. Twin International workshop to discuss the experiments with THz ad electron beams in the field of Mat. Sc. & Biological Sc. IUAC, New Delhi, June 23-25, 2021. Terahertz radiation as DNA demethylating agent: it’s prospect and challenges in cancer research.
4. 33rd Genes and Cancer Annual Meeting 2019, Robinson College, Cambridge, 8th-10th April 2019. PARP-1 inhibition synergizes induction of apoptosis and reduction of metastasis in human cancer cells by carbon ion exposure.
5. BIT’s 10th Annual World CANCER Congress – 2017, Hesperia Tower, Barcelona, Spain, May 19-21, 2017. Combined Treatment With PARP-1 Inhibitor And High LET Carbon Ion Beam Gives Promising Outcome To Control Cancer Metastasis In Cultured Human Cell Lines”.
6. International Conference on Radiation Biology (ICRB-2016), High LET Radiation Biology and Complex Natural Products in Biology & Medicine; SRM University, TN, India November 9 – 11, 2016. Carbon ion irradiation in combination with PARP-1 depletion reduces the metastatic potential in cultured human cells by suppression of its MMP activity
7. 7th International Conference on Stem Cells and Cancer (ICSSC-2016):Proliferation, Differentiation and Apoptosis; RavindraBhawan, Madgao, Goa; 21- 23 October, 2016. Combining PARP-1 inhibition with carbon ion beam treatment: A study of apoptosis and metastatic potential in HeLa cells.
8. International Conference on Radiation Biology 2014, 11th – 13th November 2014, INMAS New Delhi & ISRB; 11th – 13th November 2014. PARP-1 is a key player in controlling apoptosis induced by high LET carbon ion beam and low LET gamma radiation in HeLa cells (Oral)
9. 5th International Conference on Stem Cells and Cancer (ICSSC-2014):Proliferation, Differentiation and Apoptosis. JNU Convention centre, New Delhi; 8th – 10th November 2014. Role of PARP-1 in induction of apoptosis by high LET carbon ion beam and low LET gamma radiation in HeLa cells
10. 4th International Conference on Stem Cells and Cancer (ICSSC-2013):Proliferation, Differentiation and Apoptosis. Haffkine Institute, Parel, Mumbai, October 19-22, 2013. PARP1 is indispensable in repair of cluster DNA damage in response to carbon ion beam and induction of apoptosis in siPARP1 cells is higher than parental control cells
11. 3rd International Conference on Stem Cells and Cancer (ICSSC-2012):Proliferation, Differentiation and Apoptosis. Dr. RML Hospital, New Delhi. October 27-30, 2012. Mechanism(s) of induction of apoptosis by PARP inhibitors in K562 cells
12. 3rd World Congress on Biotechnology, 13-15 September, 2012, Hyderabad International Convention Center (HICC), Hyderabad, India OMICS publishing group, Los Angeles, USA. Induction of apoptosis by benzamide in K562 cells was triggered by inhibition of poly(ADP-ribosyl)ation of protein(s).
13. EMBO Molecular Medicine Meeting; Molecular Insights for Innovative Therapies
EMBL Heidelberg, Germany; 1- 3 Dec 2011. Inhibition of apoptosis and telomerase activity by Aurintricarboxylic acid (ATA): a biochemical and spectroscopic approach.
14. International symposium on Translational research: Cancer & Apoptosis, 18-21 December, 2005, Mascot Hotel, Trivandrum, Kerala, India. Poster on “Role of poly(ADP-ribose) polymerase (PARP) in induction of apoptosis in cultured mammalian cells”.
15. 22nd Annual convention and international symposium on recent advances in cancer causes and control, 10-12 January, 2003, RCC, Kerala, India. Poster on “Modulation of telomerase activity and apoptosis induction by PKC inhibitors in cell cull culture”.
16. MCB-INCYTE GENOMICS workshop on DNA microarray technology, 19-20 February 2001, Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.

Patents

Nil

Membership of Learned Societies

Member of Ion Beam Society of India (IBSI), [LM198], Research Network.
Member of Indian Society of Oncology (ISO) [N-G 180]
Executive Member of Society of Radiation Research (SRR) SRR/ FM-66/2023/00122

ORCID ID 0000-0002-2723-796X
Research Supervision

Ph.D. awarded (5)
1. Atanu Ghorai
Title of Thesis: Function of Poly(ADP-ribose) Polymerase-1 in high LET carbon ion beam induced DNA damage and its downstream events in human cell lines
2. Ratan Sadhukhan
Title of Thesis: Role of Poly(ADP-ribose) polymerase-1 (PARP-1) in telomere length homeostasis
3. Priyanka Chowdhury
Title of thesis: Regulation of metastasis by PARP-1 in human cancer cells in absence and presence of high LET and low LET radiation
4. Debopriya De,
Title of thesis: Screening of compounds having anti-cancer activity from crude extract of leaves of Dillenia pentagyna.
5. Sourav Ghosh,
Title of thesis: Anti-cancer studies of new G-quadruplex ligands and its in-vitro binding with target G-quadruplex DNA
6. Payel Dey, JRF, IUAC & ICMR-SRF
Title of thesis: Functional characterization of PARP1 in DDR pathway of human lung cancer A549 cells after high LET carbon ion exposure.
Ph.D. scholars presently working
1. Soumyajit Biswas (ICMR-SRF)
2. Rima Das (URS)
3. Sandipan Chatterjee (JRF-IUAC)
4. Liebig Ranjan Debnath (ICMR-JRF)
5. Roni Paul (UGC-DAE-CSR-JRF)