Utpal Ghosh

Utpal Ghosh

Utpal Ghosh

Utpal Ghosh

Department: Department of Biochemistry and Biophysics
Phone Number: 03325828750
Web URL: na
Educational Qualifications:

1999-2005 Ph.D. from Crystallography & Molecular Biology Division, Saha Institute of Nuclear Physics (SINP), Kolkata, India
1998-1999 Post-M.Sc associateship in Biophysical Sciences, SINP, Kolkata, India
1996-1998 M.Sc in Biophysics, Department of Biochemistry & Biophysics, University of Kalyani, Kalyani-741235, India
1993-1996 Diploma in Pharmacy, State Medical Faculty of West Bengal, Kolkata
1990-1993 B.Sc. (Physics Hons), University of Calcutta, Kolkata, India

Awards and Honours (National/International)

2017 Visiting Research Scientist CEA/DRF-CIMAP/GANIL- LARIA / iRCM, Bd Henri Becquerel – BP 55027, Caen, France
2016 Recipient of European Molecular Biology Organization (EMBO) short-term fellowship- ASTF-282-2016
2015 Recipient of Young Scientist Award from University of Kalyani
2012–2013 Visiting Scientist in ACTREC, Tata Memorial, Mumbai, India, under ‘The Medical Scientists Exchange Programme’ of National Academy of Medical Science (NAMS)
1999-2005 Recipient of JRF/SRF Scholarship from SINP, Kolkata
1998-1999 Recipient of Post-M.Scassociateship Scholarship from SINP, Kolkata
1990–1993 Recipient of Scholarship for the Higher secondary examination, Higher education, Bikash Bhawan, Kolkata, India

Collaborative Programs

1. Dr. Francois Chevalier, Radiobiologist, CEA, CiMAP, GANIL, Caen, France
2. Professor Subhradip Karmakar, Dept. of Biochemistry, AIIMS, New Delhi
3. Dr. Jayitri Mazumdar, Calcutta National Medical College, Kolkata-700014
4. Department of Chemistry, University of Kalyani, Kalyani, India
5. Department of Environment Sciences, University of Kalyani, Kalyani, India
6. Professor Arindam Mukherjee, Dept. of Chemical Sciences, IISER, Kolkata

Research Area:

Poly(ADP-ribose) polymerase-1 (PARP-1), a family member of PARP, can modify its target proteins post-translationally and thereby can change the function of the target proteins. PARP-1 has long been known as a key player in DNA repair and hence a number of PARP-1 inhibitors have been used as chemo-sensitizer or radio-sensitizer. However, other than DNA repair activity, it can also perform other cellular/biological functions in the cell cycle, cell differentiation, inflammation, cell death like apoptosis, cancer progression, etc. Notably, a number of PARP inhibitors (iPARP) are in clinical trials and are showing promising results against various types of cancer. For example, BRCA mutant breast cancer and ovarian cancer are potentially treated by iPARP. Besides, other solid tumors like pancreatic, colorectal, and prostate show good results. Three FDA-approved iPARP such as Olaparib, Rucaparib, and Niraparib are available in the market. However, the mechanisms of action of iPARPs in various cancer types are still poorly understood. A Study of PARP-1 in DNA repair, apoptosis, and metastasis pathways would shed light on identifying novel multiple targets for cancer therapy. Our objectives are the functional characterization of PARP-1 in the repair of cluster DNA damage, apoptosis, and metastasis pathways in cultured human cancer cells after exposure to high and low LET radiation. We also want to screen synthetic compounds and natural products with anticancer activities. Telomerase is also a well-known target for cancer therapy because about 85% of cancer cells are telomerase-positive but normal cells except a few are telomerase-negative. Telomerase replenishes telomere shortening of highly dividing cancer cells and thereby helps uncontrolled growth of cancer cells. Other than telomerase, there is another recombination-based pathway (ALT) to maintain the telomere length. PARP-1 is involved in the telomere length maintenance pathway by telomerase and ALT pathway but the exact role is yet to be elucidated. We are interested to check the role of PARP-1 in telomere length homeostasis. We are also interested to screen the compounds having apoptotic properties and anti-metastasis and anti-telomerase activities. So, we have two major areas of interest:
 Functional characterization of PARP1 in DNA repair, Apoptosis & Metastasis pathway in human cancer cells treated with high LET Carbon ion, low LET gamma radiation, synthetic and natural compounds
 Regulation of Telomerase activity and Telomere length maintenance in mammalian cells & its implication in Human diseases
Research experience using high LET carbon ion:
We have been working on DNA Damage Response (DDR) pathway in different human cancer cell lines after exposure to high LET carbon ion [62 MeV (5.2MeV/u) with LET value 290 KeV/µM]. We have been using the ion beam facility from 15UD Pelletron of Inter-University Accelerator Center (IUAC), New Delhi since 2008. Several human cancer cells are exposed to various doses of carbon ion (12C) in the presence and absence of PARP-1 inhibitor, subsequently processed for measurement of DNA damage, repair, apoptosis, and metastasis. I also worked as visiting scientist in the Radiation Biology team LARIA group, CiMAP, GANIL, Caen, France in the collaborative research project (PROJECT FONDATION ARC 2015, France; Ref no: PJA 20151203177) in the year 2017. In that project, human chondrosarcoma cells were exposed to high LET carbon ion and low LET X-rays in the presence and absence of PARP-1 inhibitor to understand the mechanism of radio-sensitization. Also used the high LET carbon ion facility of Istituto Nazionale di Fisica Nucleare (INFN), Via S. Sofia, 62, 95125 Catania CT, Italy where we compared the cellular response of chondrosarcoma to both high and low LET radiations.

Teaching Experience:

17 years experiences
Molecular biology – Transcription, post-transcriptional modification, Mutation & polymorphism and its disease relation,
Recombinant DNA technology- Cloning & expression of Proteins, RT-PCR, RAPD, AFLP; RNA interference, etc
Non-coding RNAs: siRNA, miRNA and its relation to diseases
Physic-chemical techniques –Viscosity, Sedimentation,
Biomolecular spectroscopy – Absorption, fluorescence & CD spectroscopy of biomolecules
Medical Biophysics – Radioactivity in biology, Nuclear Medicine, Endoscopy, Fibre optics, principles of Biometry

List of Publications(Peer-Reviewed)

List of publications in Peer-reviewed journals
1. p38 MAPK inhibitor SB203580 enhances anticancer activity of PARP inhibitor olaparib in a synergistic way on non-small cell lung carcinoma A549 cells. Payel Dey, Soumyajit Biswas, Rima Das, Sandipan Chatterjee, Utpal Ghosh. BBRC (2023) [IF=3.575. Elsevier; 0006-291X (print); 1090-2104 (web)]doi10.1016/j.bbrc.2023.05.116
2. High throughput screening of a new fluorescent G-quadruplex ligand having telomerase inhibitory activity in human A549 cells. Sourav Ghosh, Debapriya De, Victor Banerjee, Soumyajit Biswas, Utpal Ghosh. Nucleosides, Nucleotides & Nucleic Acids (2023) [IF=1.539, Taylor & Francis; Print ISSN 1525-7770; online ISSN:1532-2335]doi.org/10.1080/15257770.2023.2188220
3. Leaf extract and active fractions of Dillenia pentagynaRoxb. reduce in-vitro human cancer cell migration via NF‐κB pathway. Debapriya De, Priyanka Chowdhury, Sujogya Kumar Panda and Utpal Ghosh. Integr Cancer Ther. (2022) [IF=3.538; SAGE Publications; ISSN: 1534-7354 (print) 1552-695X (web)] Nov 23 2022, 21; 1-18, https://doi.org/10.1177/15347354221128832
4. Induction of apoptosis by ethanolic extract of leaf of Dillenia pentagynaRoxb. in A549 cells via NF-κB pathway. Debapriya De, Sujogya Kumar Panda and Utpal Ghosh. Phytomed plus (2022) [IF=NA; Elsevier; ISSN: 0024-3205] 14 Nov 2022; https://doi.org/10.1016/j.phyplu.2022.100368
5. PARP1 modulates telomere sister chromatid exchange and telomere length homeostasis by regulating telomere localization of SLX4 in U2OS cells. Ratan Sadhukhan, Utpal Ghosh. Life Sci (2021) [IF=5.037; Elsevier; ISSN: 0024-3205] Jul 15 [cited 2021 May 18];277:119556. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0024320521005427
6. Gamma ray induced in-vitro cell migration via EGFR/ERK/Akt/p38 activation is prevented by olaparib pre-treatment. Priyanka Chowdhury, Payel Dey, Debaprioya De, Utpal Ghosh. Int J Radiat Biol. (2020) [IF=3.352; Taylor & Francis; ISSN: 0955-3002] Jan 8:1-26. doi: 10.1080/09553002.2020.1711461.
7. Effect of Substitution at Amine Functionality of 2,6-Diaminopyridine-Coupled Rhodamine on Metal-Ion Interaction and Self-Assembly. Santanu Panja, Subhendu Mondal, Sourav Ghosh, Utpal Ghosh, and Kumaresh Ghosh. ACS Omega.[IF=4.132; ACS Publications; ISSN: 2470-1343] 2020 Jun 3; 5, 13984−13993 ;acsomega.0c01384. Available from: https://pubs.acs.org/doi/10.1021/acsomega.0c01384
8. Reduction of metastatic potential by inhibiting EGFR/Akt/p38/ERKsignaling pathway and epithelial-mesenchymal transition after carbon ion exposure is potentiated by PARP-1 inhibition in non-small-cell lung cancer. Priyanka Chowdhury, Payel Dey, Sourav Ghosh, Asitikantha Sarma,Utpal Ghosh*. BMC Cancer (2019) 19:829 . [IF=4.672 BioMed Central;ISSN:1471-2407]
9. Sensitization of chondrosarcoma cells with PARP inhibitor and high-LET radiation.Mathieu Césaire, Utpal Ghosh, Jean-Baptiste Austry, Etienne Muller, Francesco Paolo Cammarata, Marilyne Guillamin, Massimo Caruso, Laurent Castéra, Giada Petringa, Giuseppe Antonio Pablo Cirrone, François Chevalier. J Bone Oncol (2019)vol-17.[IF=4.491, Elsevier; ISSN: 2212-1374]
10. Expression of telomere-associated proteins is interdependent to stabilize native telomere structure and telomere dysfunction by G-quadruplex ligand causes TERRA up-regulation. Ratan Sadhukhan, Priyanka Choudhury, Sourav Ghosh, Utpal Ghosh*. Cell Biochem Biophys.(2018) 2018 Jun;76(1-2):311-319. doi: 10.1007/s12013-017-0835-0.accepted.[IF=2.989, Springer; ISSN: 1085-9195 (Print) 1559-0283 (Online)]
11. Application of cell-free fetal DNA for early evaluation of preeclampsia to reduce maternal mortality by low-cost method – A prospective cohort study. Mriganka Mouli Saha, Deepshikha Mukherjee, Utpal Ghosh and Subir Kumar Das. Indian J Biochem Biophys. [IF=1.476; ISSN: 0975-0959 (Online);0301-1208 (print) ] 2018;55(5):334–40.
12. C-Beam Induces More Chromosomal Damage In Chemo-Radio-Resistant Cells Than O-Beam. Utpal Ghosh, Regina Lichti Binz, Ratan Sadhukhan, Asitikantha Sarma, Subrata Kumar Dey,Martin Hauer-Jensen, Rupak Pathak. Research and Reviews: Journal of Pharmacy and pharmaceutical Sciences. e-ISSN:2320-1215; p-ISSN:2322-0112; 2018;7(2):9–14.
13. RAFT derived fatty acid based stimuli responsive fluorescent block copolymers as DNA sensor and cargo delivery agent. Lakshmipriya Datta, Debapriya De, Utpal Ghosh, Tapan Kumar Das. Polymer[IF=4.231, Elsevier; ISSN:032-3861]. 2018;138:103–12. Available from: https://doi.org/10.1016/j.polymer.2018.01.044
14. Patients with congenital limb anomaly show short telomere, shutdown of telomerase and deregulated expression of various telomere-associated proteins in PBMC; Jayitri Mazumdar1, Priyanka Chowdhury2, Tunisha Bhattacharya1, Badal Chandra Mondal1,Utpal Ghosh1*. J Clin Diagn Res (2017) DOI: 10.7860/JCDR/2017/26960.10516 Aug, Vol-11(8): GR01-GR05 [JCDR Research and Publications (P) Limited.: ISSN – 0973-709X (Online), 2249-782X (Print)]
15. Transcriptional up-regulation of TERT and TERC necessarily not mean higher telomerase activity: A report of telomerase inhibition with higher transcription of TERT, TERC and TERF2 in A549 cells treated with staurosporine. Ratan Sadhukhan and Utpal Ghosh; Int J Biotechnol Bioeng. 2017;3(1):10–5.
16. Insight into the binding of a non-toxic, self-assembling aromatic tripeptide with ct-DNA: Spectroscopic and viscositic studies. Soumi Biswas, Styabrata Samui, Arpita Chakraborty, Sagar Biswas, Debapriya De, Utpal Ghosh, Apurba K Das, Jishu Naskar. Biochem. Biophy. Rep 2017 Jul 8;11:112-118. doi: 10.1016/j.bbrep.2017.07.001. eCollection 2017 Sep.
17. αAmino Acid Derived Benzimidazole-Linked Rhodamines: A Case of Substitution Effect at the Amino Acid Site toward Spiro Ring Opening for Selective Sensing of Al3+ Ions. Anupam Majumdar, Subhendu Mondal, Constantin G Daniliuc, Debashis Sahu, Biswajit Ganguly, Sourav Ghosh, Utpal Ghosh, Kumaresh Ghosh. Inorg. Chem. 2017 Aug 7;56(15):8889-8899. doi: 10.1021/acs.inorgchem.7b00835. Epub 2017 Jul 24. [IF=4.857; ACS Publications; Print ISSN: 0020-1669; Web ISSN: 1520-510X].
18. New cyclic tetranuclear copper(II) complexes containing quadrilateral cores: synthesis, structure, spectroscopy and their interactions with DNA in aqueous solution. Gopal C. Giri,a Shobhraj Haldar,a Aloke Kumar Ghosh,b Priyanka Chowdhury,c Luca Carrella,dUtpal Ghosh,c and Manindranath Bera*. J Molecular Structure (2017) Aug 15, 1142: 175-184. doi.org/10.1016/j.molstruc.2017.04.033[IF=3.841; Elsevier; ISSN: 0022-2860].
19. Two cases of Oto palate digital syndrome type II: Clinical features and a study of telomere length maintenance pathways. Jayitri Mazumdar1, Priyanka Chowdhury2, Arundhati Banerjee1, Tunisha Bhattacharya1, Badal chandra Mondal1, Utpal Ghosh2*. Int J Med Sci Clin Inven. (2016) Dec; DOI: https://dx.doi.org/10.18535/ijmsci/v3i12.11 [VIJ; ISSN: 2348-991X; 2454-9576]
20. PARP-1 depletion in combination with carbon ion exposure significantly reduces MMPs activity and overall increases TIMPs expression in cultured HeLa cells.Atanu Ghorai, Asitikantha Sarma, Priyanka Chowdhury and Utpal Ghosh*; Radiat Oncol (2016) Sep 22; 11(1): 126.DOI: 10.1186/s13014-016-0703-x [IF=4.309 BioMed Central; ISSN: 1748-717X]
21. Synthesis and characterization of two different Cu(II) complexes with a new pyrazole based Schiff base ligand: Crystallography, DNA interaction and antimicrobial activity of Ni(II) and Cu(II) complexes. (Accepted) Susmita Mandal, RatanSadhukhan, Utpal Ghosh, Soumik Mandal, Ray J Butcher, Nitis Chandra Saha.(Accepted) J Coord Chem (2016) March 01, 1618-1634; doi.org/10.1080/00958972.2016.1174773. [IF= 2.012, Taylor & Francis; ISSN: 0095-8972 (Print), 1029-0389 (Online).
22. Carbon ion beam triggers both caspase-dependent and caspase-independent pathway of apoptosis in HeLa and status of PARP-1 controls intensity of apoptosis. Atanu Ghorai, AsitikanthaSarma, Nitai P. Bhattacharyya and Utpal Ghosh*;.Apoptosis (2015)Apr;20(4):562-80. doi: 10.1007/s10495-015-1107-3. [IF=5.561, Springer; ISSN: 1360-8185 (print version), ISSN: 1573-675X (electronic version)]
23. Interaction Studies between Biosynthesized Silver Nanoparticle with Calf Thymus DNA and Cytotoxicity of Silver Nanoparticles; Swarup Roy*, RatanSadhukhan, Utpal Ghosh, and Tapan Kumar Das .Spectrochim Acta A Mol Biomol Spectrosc (2015) Jan 29;141C:176-184. doi: 10.1016/j.saa.2015.01.041 [IF= 4.098; Elsevier; ISSN: 1386-1425].
24. Radiosensitivity and induction of apoptosis by high LET carbon ion beam and low LET gamma radiation: A comparative study. Atanu Ghorai, Nitai P. Bhattacharyya, Asitikantha Sarma and Utpal Ghosh*, Scientifica(2014) vol. 2014, Article ID 438030, 10 pages, 2014. doi:10.1155/2014/438030.[Hindawi Publishing Corporation; ISSN: 2090-908X]
25. miRNA gene counts in chromosome vary widely in a species and biogenesis of miRNA largely depends on transcription or post-transcriptional processing of coding genes. AtanuGhorai, Utpal Ghosh*. Front Genet. (2014) Apr 29;5:100. doi: 10.3389/fgene.2014.00100. eCollection 2014 [Frontiers Community; IF-4.772, ISSN: 1664-8021]
26. Green Synthesis of Gold nanoparticles for staining Human Cervical Cancer Cells and DNA binding assay. Swati De, RiktaKundu, AtanuGhorai, Ranju Prasad Mandal, UtpalGhosh J Photochem Photobiol B (2014) Aug 1;140C:130-139. doi: 10.1016/j.jphotobiol.2014.07.014. [IF=6.814; Elsevier; ISSN: 1011-1344].
27. Induction of apoptosis by benzamide in K562 cells was triggered by inhibition of poly(ADP-ribosyl)ation of protein(s). UtpalGhosh1,*Nitai P. Bhattacharyya. J. Biotechnol. & Biomaterial (2013) January 27, [OMICS Publishing Group; ISSN: 2155-952X].
28. Synthesis of novel pyrano[3,2-f]quinoline, phenanthroline derivatives and studies of their interactions with proteins: an application in mammalian cell imaging. K.C. Majumdar, Sudipta Ponra, Tapas Ghosh, Ratan Sadhukhan, Utpal Ghosh, Eur J Med Chem (2014) Jan;71:306-15. doi: 10.1016/j.ejmech.2013.10.067. Epub 2013 Nov 2.[IF = 6.514, Elsevier; ISSN: 0223-5234].
29. Synthesis, Structure, Spectroscopic Characterization and Protein Binding Affinity of New Water Soluble Hetero- and Homometallic  Tetranuclear [CuII2ZnII2] and [CuII4]  Clusters Ayan Patra, aTamal K. Sen,b Atanu Ghorai, cGhezai T Musie,*dSwadhin K. Mandal, Utpal Ghoshc and Manindranath Bera*a Inorg Chem (2013) 52 (6), pp 2880–2890. [I.F=5.436, American Chemical Society publication; ISSN: 0020-1669].
30. Synthesis, structure, interaction with DNA and cytotoxicity of a luminescent 3 copper(II) complex with a hydrazone ligand Soma Mukherjee, Santanu Chowdhury, AtanuGhorai, Utpal Ghosh, Helen Stoeckli-Evans, Polyhedron. (2013) Volume 51, 4 March 2013, Pages 228-234. [IF=3.052, Elsevier; ISSN: 0277-5387].
31. Biocapped Nanoparticles are More Bioactive to HeLa Cells than its Chemical Counterpart Utpal. Ghosh, Manickkam Nagalakshmi, Ratan. Sadhukhan, Agnishwar Girigoswami, Adv. Sci. Eng. Med. (2013). 5, Number 8, August 2013, pp. 783-788(6). [IF=0.987,American Scientific Publisher; ISSN: 2164-6627].
32. Design and synthesis of anthracene-based bispyridinium amides: anion binding, cell staining and DNA interaction studies. Kumaresh Ghosh, AvikRanjan Sarkar, AtanuGhorai and Utpal GhoshNew J Chem (2012) 36: 1231-45; DOI:10.1039/c2nj21024j. [I.F=3.591, Royal Society of Chemistry publishing; ISSN: 1144-0546].
33. Synthesis, structural characterisation and cytotoxicity of new iron(III) 3 complexes with pyrazolylthiosemicabazones; Nitis Chandra Saha, Chinmoy Biswas, AtanuGhorai, Utpal Ghosh, Saikat Kumar Seth, TanusreeKarPolyhedron (2012) 34;1-12. [IF=2.975, Elsevier; ISSN: 0277-5387].
34. A new blue luminescent dichlorido-bridged dinuclearcopper(II) complex with DNA binding and cytotoxic activities: Synthesis, structure and DFT studies. Soma Mukherjee, ChamdramaBasu, Santanu Chowdhury, Asoke P. Chattopadhyay, AtanuGhorai, Utpal Ghosh, Helen Stoeckli-Evans. Inorganica Chimica Acta, (2010), 363(12) 2752-61. [I.F=3.118, Elsevier; ISSN: 0020-1693]
35. Interaction of Aurintricarboxylic acid (ATA) with four nucleic acid binding proteins DNase I, RNase A, Reverse transcriptase and Taq polymerase. Utpal Ghosh1,*, Kalyan Giri2 and Nitai P. Bhattacharyya3.Spectrochim Acta A MolBiomolSpectrosc (2009) Dec;74(5):1145-51. Epub 2009 Sep 19. [IF=4.831, Elsevier; ISSN: 1386-1425]
36. Induction of apoptosis by the inhibitors of poly (ADP-ribose) polymerase in HeLa cells. Utpal Ghosh1,* and Nitai P. Bhattacharyya2. Mol Cell Biochem. (2009) 320:15-23. DOI 10.1007/s11010-008-9894-2 [I.F=3.842, Springer; ISSN: 0300-8177 (Print) 1573-4919 (Online)]
37. Resistance to induction of micronuclei, chromosomal aberrations and apoptosis by 60Co γ- ray in a cell strain M5, derived from Chinese hamster V79 cells. Rupak Pathak, A. R. KhudaBukhsh, S. K. Dey, Utpal Ghosh, B. Sen Gupta, M. Semwal, N. P. Bhattacharyya. J Radioanalytical & Nuclear Chemistry (2007) 274: 441-447. DOI: 10.1007/s10967-007-1134-9 [I.F=1.520, Springer; ISSN: 0236-5731 (print version) ISSN: 1588-2780 (electronic version)]
38. Inhibition of telomerase activity by reduction of poly (ADP-ribosyl)ation of TERT and TEP1/TP1 expression in HeLa cells with knocked down poly (ADP-ribose) polymerase-1 (PARP-1) gene. Utpal Ghosh, Nilanjana Das and Nitai P. Bhattacharyya. Mutat Res (2007); 615(1-2); 66-74. [I.F=3.680, Elsevier; ISSN: 0027-5107]
39. Curcumin-induced apoptosis in human leukemia cell HL-60 is associated with inhibition of telomerase activity. Sutapa Mukherjee Nee Chakraborty, Utpal Ghosh, Nitai P. Bhattacharyya, R.K. Bhattacharya, S Dey, Madhumita Roy. Mol Cell Biochem. (2007); 297 (1-2); 31-9.[I.F=2.393, Springer; ISSN: 0300-8177 (Print) 1573-4919 (Online)]
40. Activation of mitochondrial promoter PH –binding protein in a radio-resistant Chinese hamster cell strain associated with Bcl-2. Paromita Roychoudhury, Utpal Ghosh, Nitai P. Bhattacharyya, Keya Choudhury. Biochem. Biophys. Res. Commun., (2006); 350(2); 272-6.[I.F=2.523, Elsevier; ISSN: 0006-291X]
41. Inhibition of telomerase activity and induction of apoptosis by curcumin in K562 cells. Sutapa Chakraborty, Utpal Ghosh, N P Bhattacharyya, R. K. Bhattacharya &Madhumita Roy. Mutat Res. (2006); 596 (1-2); 81-90. [I.F=3.680, Elsevier; ISSN: 0027-5107]
42. Benzamide and 4-amino 1, 8 naphthalimide (NAP) treatment inhibit telomerase activity by down-regulating the expression of telomerase associated protein TEP1/TP1 and inhibiting poly(ADP-ribosyl)ation of TERT in cultured cells. Utpal Ghosh and Nitai P. Bhattacharyya, FEBS J. (2005); 272(16); 4237-48. [I.F=4.001, Wiley; ISSN: 1742-4658]
43. Induction of apoptosis by benzamide and its inhibition by aurintricarboxylic acid (ATA) in Chinese Hamster V79 cells. Utpal Ghosh, Bhaswati Pandit, Jui Dutta, N. P. Bhattacharyya. Mutat Res. (2004); 554; 121-129. [I.F=3.680, Elsevier; ISSN: 0027-5107]
44. Caspase 8 mediated apoptotic cell death induced by β-sheet forming poly alanine peptides Kalyan Giri, Utpal Ghosh., Nitai P. Bhattacharyya, SoumenBasak FEBS Lett.(2003); 555; 380-384. [I.F=3.538, Elsevier; ISSN: 0014-5793]
45. Association of fluorescent probes, ANS and bis-ANS, with T7 RNA polymerase- can they be used for folding studies of the enzyme ?Utpal Ghosh, Mili. Das, DipakDasgupta, Biopolymers (Biospectroscopy). (2003); 72; 249-255.[I.F=2.87, Wiley; ISSN: 0006-3525 (Print) 1097-0282 (Electronic)].

Books Published / Book Chapters

Book Title: Recent Advances in Natural Products
Chapter Title: Telomerase Inhibition and Apoptosis Induction by Natural Products From Plant Origin: Approaches for Cancer Chemotherapy; Utpal Ghosh, Debapriya De, Victor Banerjee. (2015); Studium Press LLC, USA

Invited Lecture / Session Chaired

1. Invited talk on “High LET carbon ion radiotherapy could be a promising approach of cancer therapy against highly aggressive human lung cancer cells” in the International Conference on Radiation Biology (ICRB-2022), organized by Department of Zoology, Govt. Dungar College, Bikaner, January 19-21, 2022.
2. Invited talk on “Terahertz radiation as a manipulator of DNA methylation: it’s prospect and challenges in cancer research” in the workshop “A Twin International Workshop (online) to discuss the experiments with THz radiation & electron beam in the field of Mat. Sc. & Bio. Sc. Inter University Accelerator Centre (IUAC), New Delhi, June 23 – 25, 2021
3. Invited talk on “Induction of apoptosis and reduction of metastasis by carbon ion beam significantly shoot up upon inhibition of PARP-1 gene by siRNA in human cervical cancer HeLa cells” in the Indo-French workshop on “Interdisciplinary investigations of ion beam interactions with matter: From fundamental aspects to nanotechnology and hadronbiology”, Caen, France 10-14 May, 2015
4. Visited the laboratory of Prof P. H. Gaillard, Scientist, CNRS, Marseille, France and delivered invited talk on ‘Cross-talk between SLX-4 and PARP-1’ December 5, 2011
5. Invited talk on ‘Role of poly(ADP-ribosyl)ation of proteins in DNA repair and apoptosis’ in the 2nd National School on Radiation Biology, November 21-25, 2011
6. Invited talk on ‘Exploring function of proteins involved in DNA damage by heavy ion beam using siRNA technology’ in the 2nd National School on Radiation Biology, November 21-25, 2011
7. Invited talk on ‘MicroRNA (miRNA): The key player in DNA Damage Response (DDR) pathway’ in the 2nd National School on Radiation Biology, November 21-25, 2011

Details of Extra Mural Research Funding

Sl. No Grant Agency Title of The Project Duration / Tenure Total Cost of The Project

SERB, Govt. of India (CRG/2022/005668/IBS)

Role of poly(ADP-ribosyl)ation reaction in telomere length homeostasis

3 years

Rs. 29,70,000/-


UGC-DAE CSR (CRS/2022-23/02/831)

Insight on gamma radiation-induced bystander effects in various human cancer cells in the presence of olaparib

30.03.2023 - 29.03.2026

Rs 11,00,000/-


IUAC, Govt. of India.

Study of metastatic potential of p53 mutant human lung cancer cells H1299 irradiated with carbon ion. (project code: BRT No 70307/RB)

30.12.2021 to 29.12.2024

Rs 11,00,000/-


IUAC, Govt. Of India,

Signaling pathways of activation and secretion of Matrix Metalloproteinases from human lung cancer cells A549 irradiated with carbon ion. (project code BTR No 60329/RB)

28.10.2016 to 27.10.2019

Rs 11,00,000/-


CSIR, Govt. Of India.

Role of PARP-1 in cluster DNA damage by high LET carbon ion beam in cultured human cell lines. Ref No - 6295/NS)

11.05.2016 to 10.05.2019

Rs 15,00,000/-


IUAC, Govt. Of India,

Investigation of DNA repair pathways and cross-talk between PARP-1 and p53 after carbon ion beam irradiation in cultured human cells. (project code BTR No 58317/RB)

16.10.2015 to 15.10.2018

Rs 11,00,000/-



Combining PARP-1 inhibition with carbon ion treatment of chondrosarcoma: study of DNA repair pathways involving poly(ADP-ribosyl)ation. (project reference: Ref nu00b0: PJA 20151203177)

09.12.2015 to 08.12.2017

EUR 50,000


DBT, Govt. Of India,

Regulation of biogenesis of Telomeric RNA and its role in telomere length maintenance, (BT/PR 4809/BRB/10/1028/2012),

03.06.2013 to 02.06.2017

Rs 44,00,000/-


DST, Govt. Of India

Functional characterization of interaction of poly(ADP-ribose)polymerase 1 (PARP-1) with telomere-binding proteins. (project code-SR/SO/BB-0017/2010)

01.09.2012 to 31.08.2015

Rs 27,00,000/-


IUAC, Govt. of India

Induction of apoptosis by heavy ion beam in Human Cervical Epithelial Carcinoma (HeLa) cells in presence and absence of PARP inhibitor. IUAC, Govt. Of India. (project code-UFUP 41335)

20.12.2007 to 19.12.2010

Rs 8,00,000/-



Membership of Learned Societies

Member of Ion Beam Society of India (IBSI), [LM198], Research Network.
Member of Indian Society of Oncology (ISO) [N-G 180]

ORCID ID 0000-0002-2723-796X
Research Supervision

Ph.D. awarded (5)
1. Atanu Ghorai
Title of Thesis: Function of Poly(ADP-ribose) Polymerase-1 in high LET carbon ion beam induced DNA damage and its downstream events in human cell lines
2. Ratan Sadhukhan
Title of Thesis: Role of Poly(ADP-ribose) polymerase-1 (PARP-1) in telomere length homeostasis
3. Priyanka Chowdhury
Title of thesis: Regulation of metastasis by PARP-1 in human cancer cells in absence and presence of high LET and low LET radiation
4. Debopriya De,
Title of thesis: Screening of compounds having anti-cancer activity from crude extract of leaves of Dillenia pentagyna.
5. Sourav Ghosh,
Title of thesis: Anti-cancer studies of new G-quadruplex ligands and its in-vitro binding with target G-quadruplex DNA
Ph.D. scholars presently working

Presently working
1. Payel Dey, JRF, IUAC & ICMR-SRF
Title of thesis: Functional characterization of PARP1 in DDR pathway of human lung cancer A549 cells after high LET carbon ion exposure.
2. Soumyajit Biswas (ICMR-SRF)
3. Rima Das (URS)
4. Sandipan Chatterjee (JRF-IUAC)