Utpal Basu
Associate Professor
Department: Department of Molecular Biology and BiotechnologyPhone Number: +91-033- 2582-8750 (EPBX) Ext: 344
Institutional E-Mail: utpal@klyuniv.ac.in
Web URL: https://klyuniv.ac.in/professors/utpal-basu/
Educational Qualifications:
Postdoc (2004-2007): University of Pennsylvania, Philadelphia, USA
Ph.D. (1998-2004): Biophysics Division, Saha Institute of Nuclear Physics, Kolkata, India
Post M.Sc. Associateship (Biophysical Sciences) (1997-98): Saha Institute of Nuclear Physics
M.Sc. (Biochemistry) (1995-97): University of Calcutta
B.Sc. (Chemistry Honours) (1992-95): University of Calcutta
Duchenne Muscular Dystrophy (DMD), the most frequent genetic disorder worldwide results from the deficiency of dystrophin. Utrophin can functionally compensate for dystrophin deficiency, but in the adult muscles, its level is low. Therefore upregulation of utrophin expression has been considered a potential therapeutic strategy for DMD. Our group studies the regulatory mechanisms of utrophin expression. We have identified two sequence elements and one upstream ORF in mouse utrophin-A 5’UTR as cis-acting repressors for utrophin expression. We have reported that the poly C binding protein 2 (PCBP2) interacts with mouse utrophin-A mRNA and results in its nuclear retention.
Group Members:
Doel Pal, Subhanwita Das, Soumyak Pal, Chhanda Sarkar, Shreya Saha
Past Group Members:
Trinath Ghosh, PhD, Ujjal Ghosh PhD, Shankhamala Bose, PhD, Sourav Gangopadhyay, Gargi Ghosh, PhD, Debasish Malik, PhD,, SK Tousif Ahamed, PhD.
Current Funding:
Science Engineering Research Board. Govt. of India.
In the Department of Molecular Biology & Biotechnology, University of Kalyani since December 2007.
List of Publications(Peer-Reviewed)1. Ghosh G, Samui S, Das S, Singh V, Pal D, Das S, Naskar N, Sinha SR, Basu U. Poly C Binding Protein 2 dependent nuclear retention of the utrophin-A mRNA in C2C12 cells. RNA Biol. 18(sup2), 612-622 (2021)
2. Malik D, Basu U. Repression-free utrophin-A 5’UTR variants. Mol Biol Res Commun 8, 129–133 (2019).
3. Ahamed ST, Roy B, Basu U, Dutta S, Ghosh AN, Bandyopadhyay B, Giri N. Genomic and proteomic characterizations of Sfin-1, a novel lytic phage infecting multidrug-resistant Shigella spp. and Escherichia coli C. Front Microbiol. 10, 1876 (2019)
4. Bose S, Karmakar J, Fulzele DP, Basu U, Bandyopadhyay TK. In vitro shoots from root explant, their encapsulation, storage, plant recovery and genetic fidelity assessment of Limonium hybrid ‘Misty Blue’: a florist plant. Plant Cell Tiss Organ Cult. 129, 313-324 (2017) 5. Ghosh S, Singh K, Shaw AK, Azahar I, Adhikari S, Ghosh U, Basu U, Roy S, Saha S, Sherpa AR, Hossain Z. Insights into the miRNA-mediated response of maize leaf to arsenate stress. Environ Exp Bot., 137, 96-109 (2017)
6. Roy S, Das TK, Maiti GP, Basu U. Microbial biosynthesis of nontoxic gold nanoparticles. Materials Science and Engineering B, 203, 41-51 (2016)
7. Ghosh T, Basu U. Cis-acting sequence elements and upstream open reading frame in mouse utrophin-A 5′-UTR repress cap-dependent translation. Plos One. 10, e0134809 (2015).
8. Ghosh U, Bose S, Ghosh T, Bandyopadhyay TK, Basu U. A Monophasic solution for isolation of RNA devoid of polymerase chain reaction-detectable genomic DNA contamination. Anal Biochem 477, 50-2 (2015).
9. Ghosh T, Ghosh U, Ghosh G, Malik D, Bose S, Basu U. Developing effective therapy for Duchenne Muscular Dystrophy (DMD): Challenges and promises. Current Chemical Biology, 8, 117-31 (2014)
10. Basu U, Lozynska O, Moorwood C, Patel G, Wilton S.D, Khurana TS. Translational regulation of utrophin by miRNAs. Plos One. 6, e29376 (2011).
11. Baby SM, Bogdanovich S, Willmann G, Basu U, Lozynska O, Khurana TS. Differential expression of utrophin-A and -B promoters in the central nervous system (CNS) of normal and dystrophic mdx mice. Brain Pathol. 20, 323-42 (2010).
12. Basu U, Gyrd-Hansen M, Baby S.M, Krag TOB, Jensen C, Frodin M, Khurana TS. Heregulin-induced epigenetic regulation of the utrophin Promoter. FEBS Letter. 581, 4153-4158 (2007).
13. Perkins KJ, Basu U, Budak M, Ketterer C, Baby SM., Lozynska O, Lunde JA, Jasmin BJ, Rubinstein NA and Khurana TS. ERF silences extra-synaptic utrophin by N-box mediated repression in skeletal muscle. Mol Biol Cell. 18, 2864-2872 (2007).
14. Basu U. and Banerjee S. An engineered EBV vector expressing human factor VIII and von Willebrand factor in cultured B-cells. Journal of Gene Medicine. 6, 760-768 (2004).
Moorwood C, Basu U, Patel G, Lozynska O, Khurana TS. Methods for enhancing utrophin production via inhibition of microRNA. United States Patent Number US 9,458,459 B2
ORCID ID https://orcid.org/0000-0002-8063-3777Current Openings
We are looking for motivated budding researchers.
